Endotoxins are small bacterially-derived hydrophobic lipopolysaccharides (LPS) molecules locating in the outer cell membrane of gram-negative bacteria. Endotoxins consist of a core polysaccharide chain, O-specific polysaccharide side chains (O-antigen) and a lipid compenent, Lipid A, which is responsible for the toxic effects. Bacteria shed endotoxin in large amounts upon cell death and when they are actively growing and dividing. A single Escherichia coli contains about 2 million LPS molecules per cell.

Endotoxin can easily contaminate labwares, and its presence can significantly impart both in vitro and in vivo experiments. And for parenteral products, parenteral products contaminated with endotoxins including LPS can lead to the development of fever, induction of inflammatory response, shock, organ failure and death in human. For dialysis products, LPS can be transferred through membrane with large pore size by back-filtration from the dialysis fluid to the blood, inflammatory problems may be caused accordingly.

Endotoxin is detected by the Lyophilized Amebocyte Lysate (LAL). Bioendo has been dedicated to researching, developing and producing LAL reagent for more than four decades. Our products cover all techniques employed to detect endotoxin, which are gel-clot technique, turbidimetric technique, and chromogenic technique.

Xiamen Bioendo Technology Co., Ltd., founded in 1978, is the expert in the field of endotoxins and Fungi (1,3)-β-D-glucan testing. Bioendo works on promoting application and development of lyophilized amebocyte lysate, and dedicates to researching, developing, producing, and marketing amebocyte lysate for four decades. Our products are registered at CFDA (China Food and Drug Administration) since 1988. We participate in preparing national standard amebocyte lysate and Reference Standard Endotoxin and standardizing Control Standard Endotoxin for the Government of China.

Cooperating with School of Life Science, Xiamen University, Xiamen Medical College, Xiamen Ocean Vocational College, and other universities, Bioendo is excellent at R&D. And supported by strong R&D strength and advanced equipment, Bioendo produces high-quality Lyophilized Amebocyte Lysate and endotoxins assay kits. Bioendo’s products mainly contain amebocyte lysate and endotoxins assay kits in gel clot technique, kinetic chromogenic, kinetic turbidimetric technique and end-point chromogenic technique, endotoxins assay kits for water and dialysate, endotoxin removal kits, clinical diagnostic assay kit for detection of fungi (1,3) β-D-glucan or invasive fungal infection, and supported items for endotoxins detection like control standard endotoxin, water for bacterial endotoxins test, endotoxin-free buffers, endotoxin challenge vials.

Bioendo also provides instruments such as Kinetic Incubating Microplate Reader, dry heat incubator, laboratory water purify system, centrifuge and other accessories.

Product range from Bioendo

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